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What is codeine for sale ? How does it work (mechanism of action)?
Codeine is a narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone. Moreover, a small amount of codeine is converted to morphine in the body. The precise mechanism of action of codeine is not known; however, like morphine, codeine binds to receptors in the brain (opioid receptors) that are important for transmitting the sensation of pain throughout the body and brain. Codeine increases tolerance to pain, decreasing discomfort, but the pain still is apparent to the patient. In addition to reducing pain, codeine also causes sedation drowsiness and depresses breathing. Codeine frequently is combined with acetaminophen (Tylenol) or aspirin for more effective pain relief. The FDA approved codeine in 1950.

What are the uses for codeine?
Codeine is used for the relief of mild to moderately severe pain and for suppressing cough.

What are the side effects of codeine?
-The most frequent side effects of codeine include:
-Shortness of breath
-Allergic reactions
-Abdominal pain

Serious side effects of codeine include:
-Life-threatening respiratory depression
-Severe low blood pressure
-Adrenal insufficiency
-Accidental ingestion of codeine can result in fatal overdose

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Is codeine addictive? Is it a controlled substance?
Codeine is habit forming (addictive). Mental and physical dependence can occur but are unlikely when used for short-term pain relief. Using codeine during pregnancy can cause opioid withdrawal syndrome in the newborn, which may be life-threatening if not treated.

Can I drink alcohol with codeine? What other drugs interact with codeine?
Codeine can impair thinking and physical abilities required for driving or operating machinery.
Alcohol and other sedatives such as alprazolam (Xanax) can produce further brain impairment and even confusion when combined with codeine.
Drugs that stimulate and also block opioid receptors (for example, pentazocine) reduce the effect of codeine.
Drugs that block the action of acetylcholine (anticholinergic drugs) increase the occurrence of urinary retention and constipation when combined with codeine.
Monoamine oxidase inhibitors (MAOIs) class of antidepressants (for example, isocarboxazid [Marplan], phenelzine [Nardil], tranylcypromine [Parnate], selegiline [Eldepryl], and procarbazine [Matulane]) significantly increase the action of codeine.
Quick Guide
Chronic Pain Syndrome: Treatment and Management for CPS
Chronic Pain Syndrome: Treatment and Management for CPS

What is the dosage for codeine?
The usual adult dose of codeine for pain is 15-60 mg every 4-6 hours as needed.
The dose for cough is 10 to 20 mg every 4-6 hours as needed.
The maximum dose for treating cough is 120 mg every 24 hours.

Is it safe to take codeine if I am pregnant or breastfeeding?
Small amounts of codeine are secreted in breast milk, but the risk of adverse events in the infant is small.

What else should I know about codeine?
Codeine is available as:
Tablets: 15, 30, 60 mg.
Solution: 15 mg/5ml (teaspoon).
Injection: 15 and 30 mg/ml.


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