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This compound had little to no history of human usage before its release in August 2015 as a newly available grey-area research chemical. It has been primarily marketed as a legal alternative to mephedrone although anecdotal reports seem to universally suggest that it is largely inferior in its recreational effects due to its weaker potency, lack of stimulation, and euphoria. It may have been developed as a result of another much more effective, but problematic mephedrone derivative, N-methoxymerphedrone.

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Buy Mexedrone Online HERE.

Buy Mexedrone online.Mexedrone is a stimulant drug of the cathinone class that has been sold online as a designer drug. It is the alpha-methoxy derivative of Mephedrone

Mexedrone (3-methoxy-2-(methylamino)-1-(p-tolyl) propane-1-one) is a putative stimulant and possible euphoriant of the cathinone chemical class with a potency of roughly 1/10th of that of mephedrone.

This compound had little to no history of human usage before its release in August 2015 as a newly available grey-area research chemical. It has been primarily marketed as a legal alternative to mephedrone although anecdotal reports seem to universally suggest that it is largely inferior in its recreational effects due to its weaker potency, lack of stimulation, and euphoria. It may have been developed as a result of another much more effective, but problematic mephedrone derivative, N-methoxymerphedrone.

 

Mexedrone
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Mexedrone, or 3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines. They contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. Amphetamines and cathinones are alpha-methylated phenethylamines. Cathinones contain an additional ketone group bonded at R1.

Mexedrone contains additional methyl substitutions at RN (similar to MDMA and methamphetamine) and R4 of its phenyl ring. Mexedrone is named for the methoxy group (C3O-) bound to the methyl group located at Rα. Mexedrone is closely analogous to mephedrone, however, mephedrone lacks the additional methoxy group bonded to the α-methyl group.

Mexedrone acts as a releasing agent of serotonin and a reuptake inhibitor for monoamine neurotransmitters serotonin, dopamine, and noradrenaline. Despite its chemical similarity to mephedrone, it lacks dopamine and noradrenaline-releasing properties and is approximately 10-20x weaker in its reuptake-inhibiting and serotonin-releasing properties.

This increase in neurotransmitters explains the euphoric and anecdotal stimulating effects induced by this experience. The serotonergic activity with a lack of significant dopaminergic and noradrenergic activity is similar to that of MDAI and consistent with usage reports that often state that mephedrone is more sedating than stimulating.

Due to the much lower potency (1/7 to 1/20th at different monoamine transporters) compared to mephedrone, considerably higher doses are required to achieve noticeable effects.

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